Relative strengths of universal detection technologies
Charged Aerosol Detection (CAD) delivers outstanding performance in all of the important criteria necessary for a universal detector. In contrast, each of the other detection technologies has significant weaknesses in its performance, limiting its usefulness as a universal HPLC detector. CAD overcomes the shortcomings of other detection methods in a single platform. None of the other detection methods are able to match the overall performance of Charged Aerosol Detection.

CAD represents a significant new universal detection option for HPLC that not only exceeds the capabilities of current options, but can push the boundaries of universal detection into areas where current methods are not able to perform. Utilization of CAD can both increase the efficiency of existing analytical operations, and open up entirely new possibilities for bioanalytical chemistry in the future.

Charged aerosol detection
is a unique technique in which theHPLC column eluent is first nebulized with nitrogen and thedroplets are dried, producing analyte particles. As the concen-tration in the peak increases, so does the size of the analyteparticle.

A secondary stream of nitrogen becomes positivelycharged as it passes a high-voltage corona wire. This charge transfers difusionally to the opposing stream of analyte particles. The amount of charge acquired is directly pro-portional to particle size.The charge is then transferred to a collector where it ismeasured by a highly sensitive electrometer, generating a signal in direct proportion to the quantity of analyte present.

Ideal for a wide range
of applications.

Corona Charged Aerosol Detection is applicable for virtually any non- or semi-volatile compound, including:

In industries such as:

• Pharmaceutical
• Foods
• Consumer products
• Industrial chemicals
• Life science research